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อาการหลักของภาวะอวัยวะคือการหายใจลำบาก ผู้ที่มีอาการนี้มักมีอาการหายใจมีเสียงหวีด แน่นหน้าอก และไม่สามารถหายใจลึกๆ ได้ เมื่อโรคลุกลาม การหายใจจะยากขึ้น อาการอื่นๆ อาจรวมถึงไอเรื้อรัง อ่อนเพลีย น้ำหนักลด และติดเชื้อทางเดินหายใจบ่อยๆ

ขั้นตอนแรกในการจัดการคือการเปลี่ยนแปลงวิถีชีวิตที่ลดผลกระทบ การเลิกบุหรี่เป็นสิ่งสำคัญสำหรับผู้ที่มีอาการนี้ ผู้ที่ยังคงสูบบุหรี่มีความเสี่ยงสูงที่จะเกิดภาวะแทรกซ้อนรุนแรง การหลีกเลี่ยงควันบุหรี่และมลพิษทางอากาศอื่นๆ การรับประทานอาหารที่มีประโยชน์และออกกำลังกายอย่างสม่ำเสมอที่เหมาะสมกับสุขภาพ(ปรึกษาแพทย์) จะช่วยให้น้ำหนักลดลง ซึ่งจะทำให้ปอดทำงานได้อย่างถูกต้อง

นอกจากการเปลี่ยนแปลงวิถีชีวิตแล้ว สั่งจ่ายยาโดยแพทย์เพื่อช่วยจัดการกับอาการ ยาขยายหลอดลมใช้เพื่อเปิดทางเดินหายใจและทำให้หายใจสะดวกขึ้น ในขณะที่ยาคอร์ติโคสเตียรอยด์ชนิดสูดดมจะลดการอักเสบในปอด การบำบัดด้วยออกซิเจนอาจจำเป็นหากระดับออกซิเจนในเลือดลดลงต่ำเกินไป อาจให้ออกซิเจนเสริมผ่านหน้ากากหรือท่อจมูกในระหว่างการรักษา

อาจแนะนำให้ทำการผ่าตัดสำหรับผู้ป่วยโรคถุงลมโป่งพองบางราย การผ่าตัดประเภทหนึ่งเกี่ยวข้องกับการเอาส่วนที่เสียหายของปอดออกเพื่อให้เนื้อเยื่อที่แข็งแรงสามารถขยายได้ การผ่าตัดควรพิจารณาหลังจากได้รับการประเมินอย่างรอบคอบโดยแพทย์แล้วเท่านั้น
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